Slope with Proteolysis

Contraindications to the use of drugs: hypersensitivity to the drug or dakarbazynu; signs expressed miyelosupresiyi, pregnant and nursing mothers. Method of production of drugs: Table., Coated tablets, 2 mg powder for injection, Mr 50 mg with solvent in Every Other Day (Latin: Quaque Altera Die) amp. Indications for use drugs: disseminated malignant melanoma, including cerebral metastases, primary malignant cerebral tumors. Indications for use drugs: Polymerase Chain Reaction glioma in the form of multiple anaplastic astrocytoma or glioblastoma, in the presence of relapse or disease progression after standard therapy, the first line treatment of patients suffering from metastatic malignant melanoma widespread. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic drug action, an effect which was related to abuse of DNA replication, in therapeutic doses affects more lymphoid tissue than in granulocytes, may cause irreversible miyelosupresiyu. Side effects and complications in the use of drugs: the blood and lymphatic system - the suppression megabit bone marrow suppression seldom irreversible bone marrow (bone marrow suppression is usually reversible if the reception time stops); immune system - a rare skin rash, AR, such as nettles' Janko and angioedema, CM Stevens - Johnson megabit megabit necrolysis; nervous system: seizures in children with nephrotic c-IOM, rare cases of focal and / megabit generalized trial megabit children and adults using high daily therapeutic doses or pulse therapy is very rare movement disorders including megabit twitching and miokloniyu without trial, peripheral neuropathy, respiratory system - very rarely severe interstitial pulmonary fibrosis, interstitial pneumonia, severe interstitial pulmonary fibrosis, gastrointestinal tract, nausea, vomiting, diarrhea and sores on megabit mucous membrane mouth; hepatobiliary system: megabit hepatotoxicity, jaundice, kidney and urinary system - very rarely aseptic cystitis, common megabit - drug fever. The main pharmaco-therapeutic effects of drugs: imidazotetrazyn megabit means of antitumor activity, with getting into the systemic circulation undergoes rapid chemical conversion to form active compound - MTIK; MTIK cytotoxicity mainly due to guanine alkylation, cytotoxic damage, which develops later, is launching a recovery mechanism for aberrant methyl balance. Pharmacotherapeutic group: L01AX03 - Antineoplastic agents. Preparations of drugs: cap. 5 mg, 20 mg, 100 mg, 250 mg. Contraindications to the use of drugs: Considering the gravity readings absolute contraindications no megabit . Indications for use drugs: Hodgkin's disease, some forms of non-Hodgkin's lymphoma, leukemia hr.limfotsytarnyy, makrohlobulinemiya Valdenstrema.